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Perioral Dermatitis: Symptoms, Causes, and Treatment

What is perioral dermatitis?

Perioral dermatitis is an inflammatory rash involving the skin around the mouth. The rash may spread up to the nose or even the eyes. In that case, it’s referred to as periorificial dermatitis.

It usually appears as a scaly or red bumpy rash around the mouth. There may be a clear fluid discharge. Redness and slight itching and burning can also occur.

Perioral dermatitis is more common in women between the ages of 16 to 45 years, but can be seen in all ages, races, and ethnicities. It also occurs in children of any age.

Without the right treatment, cases of perioral dermatitis go away, but may reappear later. Episodes of perioral dermatitis can last weeks and even months.

What causes perioral dermatitis?

The cause of perioral dermatitis is unknown. However, experts suggest that it can occur after the use of strong topical steroids on the skin. These may be prescribed to treat another condition. Nasal sprays containing corticosteroids may cause perioral dermatitis as well.

Certain ingredients in cosmetics may cause perioral dermatitis, too. Heavy skin creams that contain petrolatum or a paraffin base may cause or worsen this condition.

Other factors that may trigger this condition include:

  • bacterial or fungal infections

  • constant drooling

  • fluorinated toothpaste

  • birth control pills

  • sunscreen

  • rosacea

What are the symptoms of perioral dermatitis?

Perioral dermatitis usually appears as a rash of red bumps around the mouth and in the folds around the nose.

The bumps may be scaly in appearance. They can also appear:

  • in the area under the eyes

  • on the forehead

  • on the chin

These small bumps can contain pus or fluids. They may resemble acne.

You may experience symptoms such as burning or itching, especially as the rash worsens.

How is perioral dermatitis diagnosed?

Your doctor or dermatologist can often diagnose perioral dermatitis with just a visual examination of your skin, along with your medical history.

Your doctor may also perform a skin culture test to rule out a possible infection. During this test, your doctor will swab a small patch of skin in the affected area. They’ll send the sample to a laboratory to test the skin cells for bacteria or fungi.

Your doctor may also perform a skin biopsy, especially if the rash doesn’t respond to standard treatments.

What are the treatment options for perioral dermatitis?

The American Osteopathic College of Dermatology (AOCD) recommends stopping the use of topical steroid creams or nasal sprays containing steroids, if possible. These products can make symptoms worse and are likely responsible for the symptoms.

However, it’s important to speak with your doctor before discontinuing any medications. If you’re concerned about your condition and don’t already have a dermatologist, you can view doctors in your area through the Healthline FindCare tool.

Your doctor will determine your treatment based on the severity of your condition. In some cases, using mild soaps and discontinuing the use of heavy skin creams and fluorinated toothpaste may ease symptoms. Medications may also speed healing.

Prescription medications

Medications your doctor may prescribe to treat your condition include:

  • topical antibiotic medications, such as metronidazole (Metro gel) and erythromycin

  • immunosuppressive creams, such as pimecrolimus or tacrolimus cream

  • topical acne medications, such as adapalene or azelaic acid

  • oral antibiotics, such as doxycycline, tetracycline, minocycline, or isotretinoin, for more severe cases

Diet and lifestyle

Part of treating perioral dermatitis is incorporating lifestyle changes that can help prevent it. Consider the following:

  • Get rid of harsh face scrubs or perfumed cleansers. Instead, use only warm water during flare-ups. Once healed, only use mild soap and don’t scrub your skin.

  • Avoid steroid creams — even nonprescription hydrocortisone.

  • Stop using or reduce your use of makeup, cosmetics, and sunscreen.

  • Frequently wash your pillow cases and towels in hot water.

  • Limit overly salty or spicy foods. They can irritate skin around the mouth.

Risk factors

Some people will be more prone to or at risk of developing perioral dermatitis than others. Risk factors include:

  • sex (females are more likely to develop this condition than males)

  • use of steroid creams or ointments on the face

  • age (teenagers, young adults, and middle-aged adults are most likely to be affected)

  • a history of allergies

  • hormonal imbalances

Common triggers

There are several common triggers that can result in a perioral dermatitis outbreak. These should be avoided as much as possible.

These triggers include:

  • using a steroid cream on the face

  • makeup and cleansers that are applied to the affected or irritated area, which can make flare-ups worse

  • birth control pills

  • fluorinated toothpaste

What’s the long-term outlook?

Perioral dermatitis is difficult to treat and can last for months. According to the AOCD, even after a few weeks of treatment, the condition can get worse before it improves.

In some people, perioral dermatitis may become chronic.

How can I prevent perioral dermatitis?

Since the causes of perioral dermatitis vary and the cause isn’t completely understood, there isn’t a foolproof way to avoid getting it.

There are some things you can do to help alleviate it or to keep it from getting worse:

Avoid topical steroids

Avoid steroid creams and ointments unless specifically directed by your doctor. If another medical practitioner prescribes a topical steroid, make sure to let them know you have perioral dermatitis.

In general, it’s more likely to occur with stronger topical steroids than weaker ones. Use the weakest possible one to treat the disease.

Use cosmetics with caution

Avoid using heavy cosmetics or skin creams. Ask your doctor about which moisturizers are acceptable to use. Try switching brands if you decide to continue to use cosmetics.

Switch to gentle cleansers and moisturizers. Ask your dermatologist for recommendations that would best suit your skin.

Protect your skin

Limit the amount of time your skin comes into contact with the elements. The sun’s ultraviolet (UV) rays, heat, and wind can aggravate perioral dermatitis. Some medications used to treat perioral dermatitis will also make your skin sensitive to the sun.

Be sure to protect your skin if you’ll be in the sun for prolonged periods.


If you think you have perioral dermatitis or other skin conditions Immediate appointments are available in all our locations; Sugarloaf, Mechanicsburg, Leola, Camp Hill, Bethlehem and Gilbert… Call now or click too schedule online.

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